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Can normal cellular processes be used to fight neurodegenerative diseases?
For healthy cells, a small amount of protein misfolding and aggregation happens all the time.
These errant proteins are cleared from the cell through a normal cellular process called autophagy.
Patients with neurodegenerative diseases like Parkinson's, Huntington's, and Alzheimer's
show a build up of specific misfolded proteins
that have a tendency to aggregate
and can accumulate to cytotoxic levels.
Indeed, in some of these patients, the process of autophagy is impaired.
At Neuropore Therapies NPT520-34, one way we target diseases stemming from protein misfolding and aggregation
is by identifying novel small molecule compounds that enhance autophagy.
By designing compounds that promote clearance of a specific misfolded protein, we hope to stop disease by preventing its underlying cause—the accumulation of toxic protein aggregates.
Neuropore Therapies NPT520-34, our most advanced autophagy-promoting compound, is ready for development, and more are in the pipeline.
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